Horizon Therapeutics Ireland DAC, a designated activity company, incorporated under the laws of Ireland, registered with the Irish Companies Registration office under company number 376554 and with its parent company registered office at Connaught House, 1^st Floor, 1 Burlington Road, Dublin 4, Ireland.The Issuer is an indirect wholly-owned subsidiary of the Parent. The Issuer provides treasury services to other companies within the Horizon group. The Noteholder is an indirect subsidiary of the Parent. The Noteholder HZNP Finance Limitedprovides financing services to other companies within the Horizon group. The Noteholder’s registered office is located at H.P. House, 21 Laffan Street, Hamilton HM 09, Bermuda.

Horizon Therapeutics Ireland DAC., US$4,174,571,989 – 6.9% Promissory Note due December 31, 2029;